2024
Deng D, Begum H, Liu T, Zhang J, Zhang Q, Chu T, Li H, Lemenze A, Hoque M, Soteropoulos P, Hou P. “NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer.” J Exp Med. 2024 November 4; 221 (11): e20240766. doi: https://doi.org/10.1084/jem.20240766. full text
2023
Gulhati P, Schalck A, Jiang S, Shang X, Wu CJ, Hou P, Ruiz SH, Soto LS, Parra E, Ying H, Han J, Dey P, Li J, Deng P, Sei E, Maeda DY, Zebala JA, Spring DJ, Kim M, Wang H, Maitra A, Moore D, Clise-Dwyer K, Wang YA, Navin NE, DePinho RA. "Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer." Nat Cancer. 2023 Jan;4(1):62-80. doi: 10.1038/s43018-022-00500-z. full text
2022
Deng D, Patel R, Chiang C.-Y, Hou P. "Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance." Cells. 2022, 11, 2952. https://doi.org/10.3390/cells11192952. (corresponding author) full text
Hou P*, Wang YA. "Conquering oncogenic KRAS and its bypass mechanisms." Theranostics. 2022, 12(13): 5691-5709. doi:10.7150/thno.71260. (*corresponding author and lead contact) full text
2021
Hou P, Ma X, Yang Z, Zhang Q, Wu CJ, Li J, Tan L, Yao W, Yan L, Zhou X, Kimmelman AC, Lorenzi PL, Zhang J, Jiang S, Spring DJ, Wang YA, DePinho RA. "USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer." Genes Dev. 2021, Sep 16, doi: 10.1101/gad.348787.121. full text
Zhu M, Peng R, Liang X, Lan Z, Tang M, Hou P, Song JH, Mak CSL, Park J, Zheng SE, Huang A, Ma X, Chen R, Chang Q, Logothetis CJ, Jain AK, Lin SH, Katayama H, Hanash S, Wang G. "P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis." Oncogene. 2021 Sep 1. doi: 10.1038/s41388-021-02000-3. full text
2020
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Liao W, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Sanchez EV, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. “Telomere dysfunction activates YAP1 to drive tissue inflammation.” Nature Communications. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. full text
Hou P, Kapoor A, Zhang Q, Li J, Wu CJ, Li J, Lan Z, Tang M, Ma X, Ackroyd JJ, Kalluri R, Zhang J, Jiang S, Spring DJ, Wang YA, DePinho RA. “Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer.” Cancer Discov. 2020 Apr 27:CD-19-0597. doi: 10.1158/2159-8290.CD-19-0597. full text
2019
Hou P, Ma X, Zhang Q, Wu CJ, Liao W, Li J, Wang H, Zhao J, Zhou X, Guan C, Ackroyd J, Jiang S, Zhang J, Spring DJ, Wang YA, DePinho RA. “USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.” Genes Dev. 2019 Sep 5. doi: 10.1101/gad.326314.119. full text
Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. “Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.” Nature. 2019 Apr;568(7752):410-414. full text
2016
Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, Guo Z, Ramamoorthy V, Tieu TN, Heffernan T, Zhao D, Shang X, Khadka S, Hou P, Hu B, Jin EJ, Yao W, Pan X, Ding Z, Shi Y, Li L, Chang Q, Troncoso P, Logothetis CJ, McArthur MJ, Chin L, Wang YA, DePinho RA. “Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression.” Cancer Discov. 2016 Jan;6(1):80-95. full text
Early publications
Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. “Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds.” Science. 2013 Aug 9;341(6146):651. full text
Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. “Generation of iPSC from mouse fibroblasts with a single gene, Oct4, and small molecules.” Cell Research. (2010) :1-9. full text
Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H. “Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.” Cell Stem Cell. 2008 Dec 4;3(6):587-90. full text
Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. “Two supporting factors greatly improve the efficiency of human iPSC generation.” Cell Stem Cell. 2008 Nov 6;3(5):475-9. full text
Zheng A, Yuan F, Li Y, Zhu F, Hou P, Li J, Song X, Ding M, Deng H. “Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.” J Virol. 2007 Nov;81(22):12465-71. full text