Publications

2022

  • Hou P*#, Wang YA*. "Conquering oncogenic KRAS and its bypass mechanisms." Theranostics. 2022, doi:10.7150/thno.71260; accepted. (*co-corresponding author, #lead contact)

2021

  • Hou P, Ma X, Yang Z, Zhang Q, Wu CJ, Li J, Tan L, Yao W, Yan L, Zhou X, Kimmelman AC, Lorenzi PL, Zhang J, Jiang S, Spring DJ, Wang YA, DePinho RA. "USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer." Genes Dev. 2021, Sep 16, doi: 10.1101/gad.348787.121.

  • Zhu M, Peng R, Liang X, Lan Z, Tang M, Hou P, Song JH, Mak CSL, Park J, Zheng SE, Huang A, Ma X, Chen R, Chang Q, Logothetis CJ, Jain AK, Lin SH, Katayama H, Hanash S, Wang G. "P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis." Oncogene. 2021 Sep 1. doi: 10.1038/s41388-021-02000-3.

2020

  • Chakravarti D, Hu B, Mao X, Rashid A, Li J, Liao W, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Sanchez EV, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. “Telomere dysfunction activates YAP1 to drive tissue inflammation.” Nature Communications. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w.

  • Hou P, Kapoor A, Zhang Q, Li J, Wu CJ, Li J, Lan Z, Tang M, Ma X, Ackroyd JJ, Kalluri R, Zhang J, Jiang S, Spring DJ, Wang YA, DePinho RA. “Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer.” Cancer Discov. 2020 Apr 27:CD-19-0597. doi: 10.1158/2159-8290.CD-19-0597.

2019

  • Hou P, Ma X, Zhang Q, Wu CJ, Liao W, Li J, Wang H, Zhao J, Zhou X, Guan C, Ackroyd J, Jiang S, Zhang J, Spring DJ, Wang YA, DePinho RA. “USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.” Genes Dev. 2019 Sep 5. doi: 10.1101/gad.326314.119.

  • Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. “Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.” Nature. 2019 Apr;568(7752):410-414.

2016

  • Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, Guo Z, Ramamoorthy V, Tieu TN, Heffernan T, Zhao D, Shang X, Khadka S, Hou P, Hu B, Jin EJ, Yao W, Pan X, Ding Z, Shi Y, Li L, Chang Q, Troncoso P, Logothetis CJ, McArthur MJ, Chin L, Wang YA, DePinho RA. “Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression.” Cancer Discov. 2016 Jan;6(1):80-95.

Early publications

  • Hou P*, Li Y*, Zhang X*, Liu C*, Guan J*, Li H*, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. “Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds.” Science. 2013 Aug 9;341(6146):651 (*contributed equally to this study)

  • Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. “Generation of iPSC from mouse fibroblasts with a single gene, Oct4, and small molecules.” Cell Research. (2010) :1-9.

  • Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H. “Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.” Cell Stem Cell. 2008 Dec 4;3(6):587-90.

  • Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. “Two supporting factors greatly improve the efficiency of human iPSC generation.” Cell Stem Cell. 2008 Nov 6;3(5):475-9.

  • Zheng A, Yuan F, Li Y, Zhu F, Hou P, Li J, Song X, Ding M, Deng H. “Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.” J Virol. 2007 Nov;81(22):12465-71.